Novel Strategies for Targeting Innate Immune Responses to Influenza

We previously reported that TLR4(-/-) mice are refractory to mouse-adapted A/PR/8/34 (PR8) influenza-induced lethality and that therapeutic administration of the TLR4 antagonist, Eritoran, blocked PR8-induced lethality and acute lung injury (ALI) when given starting 2 days post-infection. Herein, we...

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Bibliografiske detaljer
Udgivet i:Mucosal Immunol
Main Authors: Shirey, Kari Ann, Lai, Wendy, Patel, Mira C., Pletneva, Lioubov M., Pang, Catherine, Kurt-Jones, Evelyn, Lipsky, Michael, Roger, Thierry, Calandra, Thierry, Tracey, Kevin, Al-Abed, Yousef, Bowie, Andrew G., Fasano, Alessio, Dinarello, Charles, Gusovsky, Fabian, Blanco, Jorge C.G., Vogel, Stefanie N.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125448/
https://ncbi.nlm.nih.gov/pubmed/26813341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2015.141
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