Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies

The standard approach to the analysis of genome-wide association studies (GWAS) is based on testing each position in the genome individually for statistical significance of its association with the phenotype under investigation. To improve the analysis of GWAS, we propose a combination of machine le...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Mieth, Bettina, Kloft, Marius, Rodríguez, Juan Antonio, Sonnenburg, Sören, Vobruba, Robin, Morcillo-Suárez, Carlos, Farré, Xavier, Marigorta, Urko M., Fehr, Ernst, Dickhaus, Thorsten, Blanchard, Gilles, Schunk, Daniel, Navarro, Arcadi, Müller, Klaus-Robert
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125008/
https://ncbi.nlm.nih.gov/pubmed/27892471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36671
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