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High Trans-ethnic Replicability of GWAS Results Implies Common Causal Variants

Genome-wide association studies (GWAS) have detected many disease associations. However, the reported variants tend to explain small fractions of risk, and there are doubts about issues such as the portability of findings over different ethnic groups or the relative roles of rare versus common varia...

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Detalhes bibliográficos
Main Authors: Marigorta, Urko M., Navarro, Arcadi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681663/
https://ncbi.nlm.nih.gov/pubmed/23785302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003566
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