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A simulation study of gene-by-environment interactions in GWAS implies ample hidden effects

The switch to a modern lifestyle in recent decades has coincided with a rapid increase in prevalence of obesity and other diseases. These shifts in prevalence could be explained by the release of genetic susceptibility for disease in the form of gene-by-environment (GxE) interactions. Yet, the detec...

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Detalhes bibliográficos
Main Authors: Marigorta, Urko M., Gibson, Greg
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104702/
https://ncbi.nlm.nih.gov/pubmed/25101110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00225
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