Deoxycholic Acid Triggers NLRP3 Inflammasome Activation and Aggravates DSS-Induced Colitis in Mice

A westernized high-fat diet (HFD) is associated with the development of inflammatory bowel disease (IBD). High-level fecal deoxycholic acid (DCA) caused by HFD contributes to the colonic inflammatory injury of IBD; however, the mechanism concerning the initiation of inflammatory response by DCA rema...

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Udgivet i:Front Immunol
Main Authors: Zhao, Shengnan, Gong, Zizhen, Zhou, Jiefei, Tian, Chunyan, Gao, Yanhong, Xu, Congfeng, Chen, Yingwei, Cai, Wei, Wu, Jin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124666/
https://ncbi.nlm.nih.gov/pubmed/27965665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00536
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