DNA polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies.

Classical genetic selection was combined with site-directed mutagenesis to study bacteriophage T4 DNA polymerase 3'----5' exonuclease activity. A mutant DNA polymerase with very little (less than or equal to 1%) 3'----5' exonuclease activity was generated. In vivo, the 3'----5' exonuclease-deficient...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Reha-Krantz, L J, Stocki, S, Nonay, R L, Dimayuga, E, Goodrich, L D, Konigsberg, W H, Spicer, E K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51243/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2006180/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2417
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