TLR8 couples SOCS-1 and restrains TLR7-mediated antiviral immunity exacerbating West Nile virus infection in mice

West Nile virus (WNV) is a neurotropic, single-stranded RNA (ssRNA) flavivirus that can cause encephalitis, meningitis, and death in humans and mice. Human Toll-like receptor (TLR) 7, 8, and mouse TLR7 recognize viral ssRNA motifs and induce antiviral immunity. However, the role of mouse TLR8 in ant...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Paul, Amber M., Acharya, Dhiraj, Le, Linda, Wang, Penghua, Stokic, Dobrivoje S., Leis, A. Arturo, Alexopoulou, Lena, Town, Terrence, Flavell, Richard A., Fikrig, Erol, Bai, Fengwei
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123688/
https://ncbi.nlm.nih.gov/pubmed/27798161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600902
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