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Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic

BACKGROUND: DNA damage response (DDR) defects imply genomic instability and favor tumor progression but make the cells vulnerable to the pharmacological inhibition of the DNA repairing enzymes. Targeting cellular proteins like PARPs, which cooperate and complement molecular defects of the DDR proces...

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Detalles Bibliográficos
Publicado en:J Exp Clin Cancer Res
Main Authors: Cerrato, Aniello, Morra, Francesco, Celetti, Angela
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123312/
https://ncbi.nlm.nih.gov/pubmed/27884198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0456-2
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