ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

Exosomes are vesicles secreted to the extracellular environment through fusion with the plasma membrane of specific endosomes called multivesicular bodies (MVB) and mediate cell-to-cell communication in many biological processes. Posttranslational modifications are involved in the sorting of specifi...

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Udgivet i:Nat Commun
Main Authors: Villarroya-Beltri, Carolina, Baixauli, Francesc, Mittelbrunn, María, Fernández-Delgado, Irene, Torralba, Daniel, Moreno-Gonzalo, Olga, Baldanta, Sara, Enrich, Carlos, Guerra, Susana, Sánchez-Madrid, Francisco
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123068/
https://ncbi.nlm.nih.gov/pubmed/27882925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13588
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