Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus

The PA N-terminal domain (PA-Nter) is essential for viral transcription and replication. Here we identified PA-Nter substitutions A37S, I61T, V63I and V100A in recently emerged avian influenza A viruses (IAVs) with potential effect on virus pathogenicity and/or host adaptation. We introduced the ide...

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Vydáno v:Sci Rep
Hlavní autoři: Hu, Meng, Chu, Hin, Zhang, Ke, Singh, Kailash, Li, Cun, Yuan, Shuofeng, Chow, Billy K. C., Song, Wenjun, Zhou, Jie, Zheng, Bo-Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122915/
https://ncbi.nlm.nih.gov/pubmed/27886255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37800
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