Caspase-8 inhibition represses initial human monocyte activation in septic shock model

In septic patients, the onset of septic shock occurs due to the over-activation of monocytes. We tested the therapeutic potential of directly targeting innate immune cell activation to limit the cytokine storm and downstream phases. We initially investigated whether caspase-8 could be an appropriate...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Oliva-Martin, Maria Jose, Sanchez-Abarca, Luis Ignacio, Rodhe, Johanna, Carrillo-Jimenez, Alejandro, Vlachos, Pinelopi, Herrera, Antonio Jose, Garcia-Quintanilla, Albert, Caballero-Velazquez, Teresa, Perez-Simon, Jose Antonio, Joseph, Bertrand, Venero, Jose Luis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
Onderwerpen:
Research Paper: Pathology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122324/
https://ncbi.nlm.nih.gov/pubmed/27250033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9648
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