Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model

Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative diseases, particularly Parkinson's disease (PD). We recently uncovered a completely novel and unexpected role for caspase-8 and its downstream substrates caspase-3/7 i...

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Vydáno v:Aging (Albany NY)
Hlavní autoři: Kavanagh, Edel, Burguillos, Miguel Angel, Carrillo-Jimenez, Alejandro, Oliva-Martin, María José, Santiago, Martiniano, Rodhe, Johanna, Joseph, Bertrand, Venero, Jose Luis
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600625/
https://ncbi.nlm.nih.gov/pubmed/26405176
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