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Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
BACKGROUND: We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and associated neurotoxicity. Importantly, a profuse non-nuclear activation of cleaved caspases 8 and 3 was found in reactive microglia in the ventral mesencephalon from subjects with P...
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| Publicado no: | J Neuroinflammation |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4302615/ https://ncbi.nlm.nih.gov/pubmed/25586882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0228-x |
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