Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism

The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. We have shown previously that neuronal S1P accumulation is toxic leading to ER-stress and an increase in intracellular calcium. To clarify the neuronal function of S...

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Publicado en:Sci Rep
Autores principales: Mitroi, Daniel N., Deutschmann, André U., Raucamp, Maren, Karunakaran, Indulekha, Glebov, Konstantine, Hans, Michael, Walter, Jochen, Saba, Julie, Gräler, Markus, Ehninger, Dan, Sopova, Elena, Shupliakov, Oleg, Swandulla, Dieter, van Echten-Deckert, Gerhild
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121647/
https://ncbi.nlm.nih.gov/pubmed/27883090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37064
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