SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production

Macroautophagy/autophagy defects have been identified as critical factors underlying the pathogenesis of neurodegenerative diseases. The roles of the bioactive signaling lipid sphingosine-1-phosphate (S1P) and its catabolic enzyme SGPL1/SPL (sphingosine phosphate lyase 1) in autophagy are increasing...

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Bibliografische gegevens
Gepubliceerd in:Autophagy
Hoofdauteurs: Mitroi, Daniel N., Karunakaran, Indulekha, Gräler, Markus, Saba, Julie D., Ehninger, Dan, Ledesma, María Dolores, van Echten-Deckert, Gerhild
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2017
Onderwerpen:
Basic Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446076/
https://ncbi.nlm.nih.gov/pubmed/28521611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1291471
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