Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein

Progressive accumulation of the amyloid β protein in extracellular plaques is a neuropathological hallmark of Alzheimer disease. Amyloid β is generated during sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. In addition to the proteolytic processing by secretases, A...

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Dettagli Bibliografici
Autori principali: Karaca, Ilker, Tamboli, Irfan Y., Glebov, Konstantin, Richter, Josefine, Fell, Lisa H., Grimm, Marcus O., Haupenthal, Viola J., Hartmann, Tobias, Gräler, Markus H., van Echten-Deckert, Gerhild, Walter, Jochen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059120/
https://ncbi.nlm.nih.gov/pubmed/24808180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.535500
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