Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein

Progressive accumulation of the amyloid β protein in extracellular plaques is a neuropathological hallmark of Alzheimer disease. Amyloid β is generated during sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. In addition to the proteolytic processing by secretases, A...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Karaca, Ilker, Tamboli, Irfan Y., Glebov, Konstantin, Richter, Josefine, Fell, Lisa H., Grimm, Marcus O., Haupenthal, Viola J., Hartmann, Tobias, Gräler, Markus H., van Echten-Deckert, Gerhild, Walter, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059120/
https://ncbi.nlm.nih.gov/pubmed/24808180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.535500
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados