Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro‐Fibrotic Signaling

BACKGROUND: Experimental uremic cardiomyopathy causes cardiac fibrosis and is causally related to the increased circulating levels of the cardiotonic steroid, marinobufagenin (MBG), which signals through Na/K‐ATPase. Rapamycin is an inhibitor of the serine/threonine kinase mammalian target of rapamy...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Haller, Steven T., Yan, Yanling, Drummond, Christopher A., Xie, Joe, Tian, Jiang, Kennedy, David J., Shilova, Victoria Y., Xie, Zijian, Liu, Jiang, Cooper, Christopher J., Malhotra, Deepak, Shapiro, Joseph I., Fedorova, Olga V., Bagrov, Alexei Y.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121507/
https://ncbi.nlm.nih.gov/pubmed/27694325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.004106
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