Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro‐Fibrotic Signaling

BACKGROUND: Experimental uremic cardiomyopathy causes cardiac fibrosis and is causally related to the increased circulating levels of the cardiotonic steroid, marinobufagenin (MBG), which signals through Na/K‐ATPase. Rapamycin is an inhibitor of the serine/threonine kinase mammalian target of rapamy...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Am Heart Assoc
Κύριοι συγγραφείς: Haller, Steven T., Yan, Yanling, Drummond, Christopher A., Xie, Joe, Tian, Jiang, Kennedy, David J., Shilova, Victoria Y., Xie, Zijian, Liu, Jiang, Cooper, Christopher J., Malhotra, Deepak, Shapiro, Joseph I., Fedorova, Olga V., Bagrov, Alexei Y.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: John Wiley and Sons Inc. 2016
Θέματα:
Original Research
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121507/
https://ncbi.nlm.nih.gov/pubmed/27694325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.004106
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