Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock

BACKGROUND: Metabolomic investigations have consistently reported succinate accumulation in plasma after critical injury. Succinate receptors have been identified on numerous tissues, and succinate has been directly implicated in post-ischemic inflammation, organ dysfunction, platelet activation and...

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Vydáno v:J Trauma Acute Care Surg
Hlavní autoři: Slaughter, Anne L., D’Alessandro, Angelo, Moore, Ernest E., Banerjee, Anirban, Silliman, Christopher C., Hansen, Kirk C., Reisz, Julie A., Fragoso, Miguel, Wither, Matthew J., Bacon, Anthony, Moore, Hunter B., Peltz, Erik D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121066/
https://ncbi.nlm.nih.gov/pubmed/27602903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001256
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