Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock

BACKGROUND: Metabolomic investigations have consistently reported succinate accumulation in plasma after critical injury. Succinate receptors have been identified on numerous tissues, and succinate has been directly implicated in post-ischemic inflammation, organ dysfunction, platelet activation and...

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Detalhes bibliográficos
Publicado no:J Trauma Acute Care Surg
Main Authors: Slaughter, Anne L., D’Alessandro, Angelo, Moore, Ernest E., Banerjee, Anirban, Silliman, Christopher C., Hansen, Kirk C., Reisz, Julie A., Fragoso, Miguel, Wither, Matthew J., Bacon, Anthony, Moore, Hunter B., Peltz, Erik D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121066/
https://ncbi.nlm.nih.gov/pubmed/27602903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001256
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