Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model

The antiviral properties of iminosugars have been reported previously in vitro and in small animal models against Ebola virus (EBOV); however, their effects have not been tested in larger animal models such as guinea pigs. We tested the iminosugars N-butyl-deoxynojirimycin (NB-DNJ) and N-(9-methoxyn...

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Pubblicato in:PLoS One
Autori principali: Miller, Joanna L., Spiro, Simon G., Dowall, Stuart D., Taylor, Irene, Rule, Antony, Alonzi, Dominic S., Sayce, Andrew C., Wright, Edward, Bentley, Emma M., Thom, Ruth, Hall, Graham, Dwek, Raymond A., Hewson, Roger, Zitzmann, Nicole
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120828/
https://ncbi.nlm.nih.gov/pubmed/27880800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167018
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