T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses

Knowledge of the processes that underlie IgG subclass switching could inform strategies designed to counteract infections and autoimmunity. Here we show that TLR7 ligands induce subsets of memory CD4 and CD8 T cells to secrete interferon γ (IFNγ) in the absence of antigen receptor stimulation. In tu...

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發表在:PLoS One
Main Authors: Rubtsova, Kira, Rubtsov, Anatoly V., Halemano, Kalani, Li, Sam X., Kappler, John W., Santiago, Mario L., Marrack, Philippa
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120817/
https://ncbi.nlm.nih.gov/pubmed/27880772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166322
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