SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis

Although cancers are considered stem cell diseases, mechanisms involving stem cell alterations are poorly understood. Squamous cell carcinoma (SQCC) is the second most common lung cancer, and its pathogenesis appears to hinge on changes in the stem cell behavior of basal cells in the bronchial airwa...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Kim, Bo Ram, Van de Laar, Emily, Cabanero, Michael, Tarumi, Shintaro, Hasenoeder, Stefan, Wang, Dennis, Virtanen, Carl, Suzuki, Takaya, Bandarchi, Bizhan, Sakashita, Shingo, Pham, Nhu An, Lee, Sharon, Keshavjee, Shaf, Waddell, Thomas K., Tsao, Ming-Sound, Moghal, Nadeem
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120804/
https://ncbi.nlm.nih.gov/pubmed/27880766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002581
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