Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in Vivo

BACKGROUND: GTP cyclohydrolase 1 (GCH1) deficiency is critical for endothelial nitric oxide synthase uncoupling in endothelial dysfunction. MicroRNAs (miRs) are a class of regulatory RNAs that negatively regulate gene expression. We investigated whether statins prevent endothelial dysfunction via mi...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Li, Peng, Yin, Ya-Ling, Guo, Tao, Sun, Xue-Ying, Ma, Hui, Zhu, Mo-Li, Zhao, Fan-Rong, Xu, Ping, Chen, Yuan, Wan, Guang-Rui, Jiang, Fan, Peng, Qi-Sheng, Liu, Chao, Liu, Li-Ying, Wang, Shuang-Xi
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120771/
https://ncbi.nlm.nih.gov/pubmed/27765794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.017949
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