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Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling
The accumulation of prelamin A is linked to disruption of cellular homeostasis, tissue degeneration and aging. Its expression is implicated in compromised genome stability and increased levels of DNA damage, but to date there is no complete explanation for how prelamin A exerts its toxic effects. As...
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| Publicado no: | Nucleus |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5120601/ https://ncbi.nlm.nih.gov/pubmed/27676213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1239685 |
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