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Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid

We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer Disease is OSA leading to decreased slow wave activity, increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were per...

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Detalles Bibliográficos
Publicado en:Ann Neurol
Main Authors: Ju, Yo-El S., Finn, Mary Beth, Sutphen, Courtney L., Herries, Elizabeth M., Jerome, Gina M., Ladenson, Jack H., Crimmins, Daniel L., Fagan, Anne M., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120585/
https://ncbi.nlm.nih.gov/pubmed/27129429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24672
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