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Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid

We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer Disease is OSA leading to decreased slow wave activity, increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were per...

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Vydáno v:Ann Neurol
Hlavní autoři: Ju, Yo-El S., Finn, Mary Beth, Sutphen, Courtney L., Herries, Elizabeth M., Jerome, Gina M., Ladenson, Jack H., Crimmins, Daniel L., Fagan, Anne M., Holtzman, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120585/
https://ncbi.nlm.nih.gov/pubmed/27129429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24672
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