Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease

IMPORTANCE: Neurogranin (NGRN) seems to be a promising novel cerebrospinal fluid (CSF) biomarker for synaptic loss; however, clinical, and especially longitudinal, data are sparse. OBJECTIVE: To examine the utility of NGRN, with repeated CSF sampling, for diagnosis, prognosis, and monitoring of Alzh...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Kester, Maartje I., Teunissen, Charlotte E., Crimmins, Daniel L., Herries, Elizabeth M., Ladenson, Jack. H., Scheltens, Philip, van der Flier, Wiesje M., Morris, John C., Holtzman, David M., Fagan, Anne M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694558/
https://ncbi.nlm.nih.gov/pubmed/26366630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2015.1867
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