Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease

IMPORTANCE: Neurogranin (NGRN) seems to be a promising novel cerebrospinal fluid (CSF) biomarker for synaptic loss; however, clinical, and especially longitudinal, data are sparse. OBJECTIVE: To examine the utility of NGRN, with repeated CSF sampling, for diagnosis, prognosis, and monitoring of Alzh...

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Опубликовано в: :JAMA Neurol
Главные авторы: Kester, Maartje I., Teunissen, Charlotte E., Crimmins, Daniel L., Herries, Elizabeth M., Ladenson, Jack. H., Scheltens, Philip, van der Flier, Wiesje M., Morris, John C., Holtzman, David M., Fagan, Anne M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694558/
https://ncbi.nlm.nih.gov/pubmed/26366630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2015.1867
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