sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

TREM2 is an innate immune receptor expressed on the surface of microglia. Loss‐of‐function mutations of TREM2 are associated with increased risk of Alzheimer's disease (AD). TREM2 is a type‐1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as...

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Detaylı Bibliyografya
Yayımlandı:EMBO Mol Med
Asıl Yazarlar: Suárez‐Calvet, Marc, Kleinberger, Gernot, Araque Caballero, Miguel Ángel, Brendel, Matthias, Rominger, Axel, Alcolea, Daniel, Fortea, Juan, Lleó, Alberto, Blesa, Rafael, Gispert, Juan Domingo, Sánchez‐Valle, Raquel, Antonell, Anna, Rami, Lorena, Molinuevo, José L, Brosseron, Frederic, Traschütz, Andreas, Heneka, Michael T, Struyfs, Hanne, Engelborghs, Sebastiaan, Sleegers, Kristel, Van Broeckhoven, Christine, Zetterberg, Henrik, Nellgård, Bengt, Blennow, Kaj, Crispin, Alexander, Ewers, Michael, Haass, Christian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120370/
https://ncbi.nlm.nih.gov/pubmed/26941262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201506123
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