Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism

Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), a class B G-protein-coupled receptor. Hypoparathyroidism and osteoporosis can be treated with PTH injections; however, no orally effective PTH analogue is available. Here we...

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Publicado no:Nat Commun
Main Authors: Tamura, Tatsuya, Noda, Hiroshi, Joyashiki, Eri, Hoshino, Maiko, Watanabe, Tomoyuki, Kinosaki, Masahiko, Nishimura, Yoshikazu, Esaki, Tohru, Ogawa, Kotaro, Miyake, Taiji, Arai, Shinichi, Shimizu, Masaru, Kitamura, Hidetomo, Sato, Haruhiko, Kawabe, Yoshiki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120204/
https://ncbi.nlm.nih.gov/pubmed/27857062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13384
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