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Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models

BACKGROUND: Methotrexate (MTX) is one of the most widely used medications to treat rheumatoid arthritis (RA), and recent studies have also suggested the potential benefit of the drug for the treatment of osteoarthritis (OA) of the knee. MTX is commonly administered in oral formulations, but is often...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Tamura, Tatsuya, Higuchi, Yoshinobu, Kitamura, Hidetomo, Murao, Naoaki, Saitoh, Ryoichi, Morikawa, Tadashi, Sato, Haruhiko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818416/
https://ncbi.nlm.nih.gov/pubmed/27039182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0971-8
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