Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells

Autoimmune regulator (Aire) is a transcriptional regulator of peripheral tissue antigens (PTAs) and microRNAs (miRNAs) in medullary thymic epithelial cells (mTECs). In this study, we tested the hypothesis that Aire also played a role as an upstream posttranscriptional controller in these cells and t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Oliveira, Ernna H., Macedo, Claudia, Collares, Cristhianna V., Freitas, Ana Carolina, Donate, Paula Barbim, Sakamoto-Hojo, Elza T., Donadi, Eduardo A., Passos, Geraldo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120147/
https://ncbi.nlm.nih.gov/pubmed/27933063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00526
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