Development of Type 1 Diabetes Mellitus in Nonobese Diabetic Mice Follows Changes in Thymocyte and Peripheral T Lymphocyte Transcriptional Activity

As early as one month of age, nonobese diabetic (NOD) mice feature pancreatic infiltration of autoreactive T lymphocytes, which destruct insulin-producing beta cells, producing autoimmune diabetes mellitus (T1D) within eight months. Thus, we hypothesized that during the development of T1D, the trans...

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Bibliographic Details
Main Authors: Fornari, Thais A., Donate, Paula B., Macedo, Claudia, Sakamoto-Hojo, Elza T., Donadi, Eduardo A., Passos, Geraldo A.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135058/
https://ncbi.nlm.nih.gov/pubmed/21765850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/158735
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