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Thrombotic Stroke: Neuroprotective Therapy by Recombinant Activated Protein C

Activated protein C (APC), derived from the plasma protease zymogen, protein C, is antithrombotic and anti-inflammatory. In preclinical injury models, recombinant APC provides neuroprotection for multiple injuries, including ischemic stroke. APC acts directly on brain endothelial cells and neurons b...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Griffin, John H., Mosnier, Laurent O., Fernández, José A., Zlokovic, Berislav V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119536/
https://ncbi.nlm.nih.gov/pubmed/27758767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308038
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