Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group study

OBJECTIVE: Rapamycin analogs have reproducible but modest efficacy in endometrial cancer (EC). Identification of molecular biomarkers that predict benefit could guide clinical development. METHODS: Fixed primary tissue and whole blood were collected prospectively from patients enrolled on GOG 248. D...

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Detalhes bibliográficos
Publicado no:Gynecol Oncol
Main Authors: Myers, Andrea P., Filiaci, Virginia L., Zhang, Yuping, Pearl, Michael, Behbakht, Kian, Makker, Vicky, Hanjani, Parviz, Zweizig, Susan, Burke, James J., Downey, Gordon, Leslie, Kimberly K., Van Hummelen, Paul, Birrer, Michael J., Fleming, Gini F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119517/
https://ncbi.nlm.nih.gov/pubmed/27016228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2016.02.025
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