Mycobacterium tuberculosis Arylamine N-Acetyltransferase Acetylates and Thus Inactivates para-Aminosalicylic Acid

Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) is able to acetylate para-aminosalicylic acid (PAS) both in vitro and in vivo as determined by high-performance liquid chromatography (HPLC) and electrospray ionization-mass spectrometry (ESI-MS) techniques. The antituberculosis activi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Wang, Xude, Yang, Shanshan, Gu, Jing, Deng, Jiaoyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119037/
https://ncbi.nlm.nih.gov/pubmed/27671064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01312-16
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