Breaking the Permeability Barrier of Escherichia coli by Controlled Hyperporination of the Outer Membrane

In Gram-negative bacteria, a synergistic relationship between slow passive uptake of antibiotics across the outer membrane and active efflux transporters creates a permeability barrier, which efficiently reduces the effective concentrations of antibiotics in cells and, hence, their activities. To an...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Krishnamoorthy, Ganesh, Wolloscheck, David, Weeks, Jon W., Croft, Cameron, Rybenkov, Valentin V., Zgurskaya, Helen I.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119019/
https://ncbi.nlm.nih.gov/pubmed/27697764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01882-16
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