p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming

Human induced pluripotent stem (iPS) cells have great potential in regenerative medicine, but this depends on the integrity of their genomes. iPS cells have been found to contain a large number of de novo genetic alterations due to DNA damage response during reprogramming. Thus, to maintain the gene...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gong, Lu, Pan, Xiao, Chen, Haide, Rao, Lingjun, Zeng, Yelin, Hang, Honghui, Peng, Jinrong, Xiao, Lei, Chen, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118801/
https://ncbi.nlm.nih.gov/pubmed/27874035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37281
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