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In-depth comparison of somatic point mutation callers based on different tumor next-generation sequencing depth data

Four popular somatic single nucleotide variant (SNV) calling methods (Varscan, SomaticSniper, Strelka and MuTect2) were carefully evaluated on the real whole exome sequencing (WES, depth of ~50X) and ultra-deep targeted sequencing (UDT-Seq, depth of ~370X) data. The four tools returned poor consensu...

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Detalles Bibliográficos
Publicado en:Sci Rep
Autores principales: Cai, Lei, Yuan, Wei, Zhang, Zhou, He, Lin, Chou, Kuo-Chen
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118795/
https://ncbi.nlm.nih.gov/pubmed/27874022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36540
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