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Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes
In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ags) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY Ser codons are far more abundant in complement...
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| Pubblicato in: | Front Immunol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5118421/ https://ncbi.nlm.nih.gov/pubmed/27920779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00525 |
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