Somatically Hypermutated Plasmodium-Specific IgM(+) Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge

Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells and rapidly reactive memory B cells (MBC). Recent studies of MBC development and function after protein immunization have uncovered significant MBC heterogeneity. To clarify functional roles for distinct MBC su...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Krishnamurty, Akshay T., Thouvenel, Christopher D., Portugal, Silvia, Keitany, Gladys J., Kim, Karen S., Holder, Anthony, Crompton, Peter D., Rawlings, David J., Pepper, Marion
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118370/
https://ncbi.nlm.nih.gov/pubmed/27473412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.06.014
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