Detection of gene–environment interaction in pedigree data using genome-wide genotypes

Heritability may be estimated using phenotypic data collected in relatives or in distantly related individuals using genome-wide single nucleotide polymorphism (SNP) data. We combined these approaches by re-parameterizing the model proposed by Zaitlen et al and extended this model to include moderat...

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Veröffentlicht in:Eur J Hum Genet
Hauptverfasser: Nivard, Michel G, Middeldorp, Christel M, Lubke, Gitta, Hottenga, Jouke-Jan, Abdellaoui, Abdel, Boomsma, Dorret I, Dolan, Conor V
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117937/
https://ncbi.nlm.nih.gov/pubmed/27436263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2016.88
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