Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model

Holoprosencephaly (HPE) is a common and severe human developmental abnormality marked by malformations of the forebrain and face. Although several genetic mutations have been linked to HPE, phenotypic outcomes range dramatically, and most cases cannot be attributed to a specific cause. Gene-environm...

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Bibliografski detalji
Izdano u:Dis Model Mech
Glavni autori: Heyne, Galen W., Everson, Joshua L., Ansen-Wilson, Lydia J., Melberg, Cal G., Fink, Dustin M., Parins, Kia F., Doroodchi, Padydeh, Ulschmid, Caden M., Lipinski, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117230/
https://ncbi.nlm.nih.gov/pubmed/27585885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.026328
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