Gli2 gene-environment interactions contribute to the etiological complexity of holoprosencephaly: evidence from a mouse model

Holoprosencephaly (HPE) is a common and severe human developmental abnormality marked by malformations of the forebrain and face. Although several genetic mutations have been linked to HPE, phenotypic outcomes range dramatically, and most cases cannot be attributed to a specific cause. Gene-environm...

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Detalles Bibliográficos
Publicado en:Dis Model Mech
Autores principales: Heyne, Galen W., Everson, Joshua L., Ansen-Wilson, Lydia J., Melberg, Cal G., Fink, Dustin M., Parins, Kia F., Doroodchi, Padydeh, Ulschmid, Caden M., Lipinski, Robert J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117230/
https://ncbi.nlm.nih.gov/pubmed/27585885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.026328
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