Macrophages Promote Oxidative Metabolism To Drive Nitric Oxide Generation in Response to Trypanosoma cruzi

Trypanosoma cruzi is the causative agent of chronic chagasic cardiomyopathy. Why macrophages (mφs), the early responders to infection, fail to achieve parasite clearance is not known. Mouse (RAW 264.7) and human (THP-1 and primary) mφs were infected for 3 h and 18 h with T. cruzi TcI isolates, Sylvi...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Koo, Sue-jie, Chowdhury, Imran H., Szczesny, Bartosz, Wan, Xianxiu, Garg, Nisha J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Fungal and Parasitic Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116729/
https://ncbi.nlm.nih.gov/pubmed/27698021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00809-16
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