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Phospho-BRD4: Transcription Plasticity and Drug Targeting
BRD4 is an epigenetic regulator and transcription cofactor whose phosphorylation by CK2 and dephosphorylation by PP2A modulates its function in chromatin targeting, factor recruitment, and cancer progression. While the bromodomains of BET family proteins, including BRD4, BRD2, BRD3 and BRDT, have be...
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| Publicado no: | Drug Discov Today Technol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5116322/ https://ncbi.nlm.nih.gov/pubmed/27769352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2016.05.003 |
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