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Phospho-BRD4: Transcription Plasticity and Drug Targeting

BRD4 is an epigenetic regulator and transcription cofactor whose phosphorylation by CK2 and dephosphorylation by PP2A modulates its function in chromatin targeting, factor recruitment, and cancer progression. While the bromodomains of BET family proteins, including BRD4, BRD2, BRD3 and BRDT, have be...

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Bibliografiske detaljer
Udgivet i:Drug Discov Today Technol
Hovedforfatter: Chiang, Cheng-Ming
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116322/
https://ncbi.nlm.nih.gov/pubmed/27769352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2016.05.003
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