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Phospho-BRD4: Transcription Plasticity and Drug Targeting
BRD4 is an epigenetic regulator and transcription cofactor whose phosphorylation by CK2 and dephosphorylation by PP2A modulates its function in chromatin targeting, factor recruitment, and cancer progression. While the bromodomains of BET family proteins, including BRD4, BRD2, BRD3 and BRDT, have be...
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| Опубликовано в: : | Drug Discov Today Technol |
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| Главный автор: | |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5116322/ https://ncbi.nlm.nih.gov/pubmed/27769352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2016.05.003 |
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