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Clinical trials for BET inhibitors run ahead of the science

Several cancer clinical trials for small molecule inhibitors of BET bromodomain proteins have been initiated. There is enthusiasm for the anti-proliferative effect of inhibiting BRD4, one of the targets of these inhibitors, which is thought to cooperate with MYC, a long-desired target for cancer the...

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Publicat a:Drug Discov Today Technol
Autors principals: Andrieu, Guillaume, Belkina, Anna C., Denis, Gerald V.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116321/
https://ncbi.nlm.nih.gov/pubmed/27769357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ddtec.2016.06.004
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