In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development

Signalling pathway activation analysis is a powerful approach for extracting biologically relevant features from large-scale transcriptomic and proteomic data. However, modern pathway-based methods often fail to provide stable pathway signatures of a specific phenotype or reliable disease biomarkers...

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Pubblicato in:Nat Commun
Autori principali: Ozerov, Ivan V., Lezhnina, Ksenia V., Izumchenko, Evgeny, Artemov, Artem V., Medintsev, Sergey, Vanhaelen, Quentin, Aliper, Alexander, Vijg, Jan, Osipov, Andreyan N., Labat, Ivan, West, Michael D., Buzdin, Anton, Cantor, Charles R., Nikolsky, Yuri, Borisov, Nikolay, Irincheeva, Irina, Khokhlovich, Edward, Sidransky, David, Camargo, Miguel Luiz, Zhavoronkov, Alex
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116087/
https://ncbi.nlm.nih.gov/pubmed/27848968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13427
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