In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development

Signalling pathway activation analysis is a powerful approach for extracting biologically relevant features from large-scale transcriptomic and proteomic data. However, modern pathway-based methods often fail to provide stable pathway signatures of a specific phenotype or reliable disease biomarkers...

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Publicado no:Nat Commun
Main Authors: Ozerov, Ivan V., Lezhnina, Ksenia V., Izumchenko, Evgeny, Artemov, Artem V., Medintsev, Sergey, Vanhaelen, Quentin, Aliper, Alexander, Vijg, Jan, Osipov, Andreyan N., Labat, Ivan, West, Michael D., Buzdin, Anton, Cantor, Charles R., Nikolsky, Yuri, Borisov, Nikolay, Irincheeva, Irina, Khokhlovich, Edward, Sidransky, David, Camargo, Miguel Luiz, Zhavoronkov, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116087/
https://ncbi.nlm.nih.gov/pubmed/27848968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13427
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