BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

Oncogene-evoked replication stress (RS) fuels genomic instability in diverse cancer types. Here we report that BRCA1, traditionally regarded a tumour suppressor, plays an unexpected tumour-promoting role in glioblastoma (GBM), safeguarding a protective response to supraphysiological RS levels. Highe...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Rasmussen, Rikke D., Gajjar, Madhavsai K., Tuckova, Lucie, Jensen, Kamilla E., Maya-Mendoza, Apolinar, Holst, Camilla B., Møllgaard, Kjeld, Rasmussen, Jane S., Brennum, Jannick, Bartek, Jiri, Syrucek, Martin, Sedlakova, Eva, Andersen, Klaus K., Frederiksen, Marie H., Hamerlik, Petra
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116074/
https://ncbi.nlm.nih.gov/pubmed/27845331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13398
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